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Additional clinical considerations include: previous weight loss attempts (lifestyle modifications should generally be attempted first), cardiovascular risk profile, family history of medullary thyroid carcinoma (a contraindication for GLP-1 agonists), history of pancreatitis, current medications, mental health status, and pregnancy planning (GLP-1 agonists must be discontinued at least 2 months before conception)

Thus, the data suggest that the synergistic response to GHRP2 in-vivo, is not dose related to endogenous GHRH, but rather just requires the presence of some quantum of the natural hormone to realize a significant part of its full stimulatory potential

Side effects, contraindications, and personal health history all need to be carefully considered

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