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FDA press announcement (2023) 12

3 GLP-1 agonists and lifestyle interventions: efficacy, benefits, and limitations for weight control and metabolic health GLP-1RAs consistently demonstrate significant weight loss (mean reductions of 79 kg of body weight over a period of about a year) and improvements in BMI, waist circumference, blood pressure, and lipid profiles in both diabetic and non-diabetic populations ( Lifestyle interventions, including exercise and dietary modification, remain the cornerstone of obesity and diabetes management, with proven benefits for weight loss, glycemic control, cardiovascular health, and quality of life ( 3.1 GLP-1 agonists and exercise: comparative and combined effects Direct comparisons reveal that GLP-1RAs generally produce greater short-term weight loss than exercise alone, but exercise is superior for maintaining lean mass and cardiorespiratory fitness ( Recent randomized controlled trials show that combining GLP-1RAs with exercise yields additive benefits, including greater reductions in metabolic syndrome severity, abdominal obesity, oxidative stress and inflammation, and improved weight loss maintenance after cessation of pharmacotherapy ( Interestingly, recent evidence highlights the interconnection between exercise-induced interleukin-6 (IL-6) secretion and GLP-1RAs

Baseline Labs Before First Dose Order a complete metabolic panel (CMP), IGF-1 (age/sex referenced), HbA1c, fasting insulin, CBC, and a Child-Pugh score calculation using bilirubin, albumin, PT/INR, and clinical ascites and encephalopathy staging

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