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There are scattered reports of hormonal and mood effects, though the research here is limited

Whether that produces a meaningfully different result depends on the individual

It is associated with progressive health conditions such as heart failure

Lancet Infect Dis 13:976986 Cohen J, DAgostino L, Wilson J, Tuzer F, Torres C (2017) Astrocyte senescence and metabolic changes in response to HIV Antiretroviral Therapy drugs