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LTB4, leukotriene B4
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It has a neuroendocrine pathway independent of the GLP-1 receptors, working by stimulating melanocortin-4 receptors (MC4R) to reduce hunger and increase basal metabolic rate
The glucose-lowering effects of SGLT2 inhibitors are achieved via glucosuria, and are comparatively modest, reducing HbA1c by 0.5-0.7% in patients with normal kidney function, and lesser effects are seen in patients with CKD stage 3 or 4 2 , 44
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