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Samples were incubated at room temperature for 1 h, vortexing intermittently, and then quenched by the addition of hydroxylamine (5 L of 5% w/v in HPLC water per sample) and incubated for 15 min at room temperature

Some individuals may experience mild, temporary symptoms such as stomach upset or changes in bowel habits

Recruitment has also begun for PIONEER 12, which is projected to be completed in August of 2021

Early-onset illness is associated with the additional risk factor of longer delay to first treatment, and early onset and treatment delay are both independent risk factors for a poor outcome in adulthood