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On October 3, 2024, the US Food and Drug Administration (FDA) revised its shortage categorization of tirzepatide, a glucagon-like peptide 1 (GLP-1) medication, marking the shortage as resolved for all presentations of the drug

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Tirzepatide's pharmacokinetic engineering builds on GLP-1 agonist acylation principles but applies them to a GIP-backbone peptide, producing a dual-receptor agonist with a 5-day half-life

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