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Some research suggests that an imbalance in gut bacteria may contribute to certain types of constipation, including irritable bowel syndrome with constipation (IBS-C) ( Taking probiotic supplements may help support a balanced gut microbiome

Notably, IGF-1 LR3 enhances muscle sensitivity to insulin, thereby promoting glucose uptake and utilization while simultaneously reducing fat storage

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The number of animals assigned per condition was selected to account for the variability of the examined phenotypes based on pilot experiment and past experience with the animal models (6 animals per experimental condition)