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As discussed before in this manuscript, BBB breakdown is considered to be the basic pathophysiology of HT, and BBBP is directly correlated with the appearance of subsequent HT, suggesting that the assessment of the BBB permeability should be the most promising predictor of HT (154)

doi: 10.3389/fimmu.2026.1750304 Received 20 November 2025 Revised 21 January 2026 Accepted 30 January 2026 Published 18 February 2026 Corrected 26 March 2026 Volume 17 - 2026 Edited by Rajiv Kumar, Banaras Hindu University, India Reviewed by Aislan Carvalho Vivarini, Federal University of Rio de Janeiro, Brazil Lovlesh Thakur, Cleveland State University, United States Updates Copyright 2026 Onwah, Gupta, Zayats, Banga, Chhotaria, Ahluwalia and Uzonna