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Xiang M, Lu Y, Xin L, Gao J, Shang C, Jiang Z, et al

Patients with MTHFR polymorphisms or elevated homocysteine may require 1ml twice weekly or a single 2ml injection weekly to achieve adequate methylation support

Central nervous system effects may include various degrees of encephalopathy, cognitive and memory deficits, impaired concentration, and diminished executive function