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Option (Evidence Strength: Grade C) Major Surgery Major surgery (e.g., substitution cystoplasty, urinary diversion with or without cystectomy) may be undertaken in carefully selected patients with bladder-centric symptoms, or in the rare instance when there is an end-stage small fibrotic bladder, for whom all other therapies have failed to provide adequate symptom control and quality of life improvement
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Role of glutathione redox status in liver injury
Our experience working with research-grade peptides has shown us that mechanistic plausibility and short-term safety data are necessary but not sufficient conditions for declaring a compound safe at extended durations
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