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In animal models the parent compound is described as relatively short-lived in plasma but with effects persisting longer than the systemic exposure window a profile the Zagreb group attributes to its stability in the gastrointestinal lumen and to downstream signaling cascades (Sikiric et al., 2018)
Moreover, they are known to reduce signs of skin aging
Further studies could provide pre-clinical evidence supporting apigenins translational potential in TBI management
Users have reported faster recovery times and reduced inflammation, although comprehensive clinical trials in humans are still limited
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