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Proc Nat Acad Sci USA 1989

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Dysbiotic colonies with their LPS-induced COX - 2 expression may mediate the development of GERD, a study treated rats with LPS as well as different prostaglandins and COX - 2 inhibitors and showed that the use of COX - 2 inhibitors blocked LPS-induced delayed gastric emptying, which is a possible risk factor for GERD (53, 54)