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Conversely, genes implicated in the oxidative stress response and DNA modifications, such as those encoding GPx activity and HBL79_RS11455 , a Class I SAM-dependent DNA methyltransferase, were upregulated, suggesting increased defense against oxidative damage and potential alterations in DNA methylation patterns that may facilitate the bacteriums adaptation to increased oxidative stress conditions (Figures 4G and H)

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Some previous studies had smaller sample sizes and short follow-up times, which cast doubt on the beneficial effects of GLP-1 RAs against DR

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