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Diabetes GLP-1s perform better but still leak demand: Diabetes-indicated GLP-1s show higher retention (24% at one year) and face fewer access hurdles due to broader coverage and disease framing, yet 76% of demand remains unmet

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Tirzepatide's Zepbound label reports similar figures, with nausea at 31% and constipation at 17% at the 15 mg dose in SURMOUNT-1 [2][4]

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When the body can no longer adequately keep up, blood glucose may rise to diabetic levels

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