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It was reported that Weibull parameter could be used to predict the period before an AE occured and provided relevant insights for patient pharmacological management in clinical practice ( Among the 45 gastrointestinal AEs, 17 new and unexpected AEs, including dry mouth, hypophagia, gastrointestinal sounds abnormal, bowel movement irregularity, feces discolored, pancreatic carcinoma metastatic, etc, were detected in our pharmacovigilance study, which were not reported in the drug label
PMCID: PMC4406950
This helps to increase feelings of satiety and reduce hunger signals throughout the body
Electrophysiological recordings support this notion and have demonstrated that GLP-1 directly stimulates POMC/CART cells, whereas GLP-1 can also inhibit orexigenic NPY/AgRP cells in the ARC through an indirect mechanism (Secher et al., 2014)
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