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Clinically relevant weight loss is achieved independently of early weight loss response to once-weekly subcutaneous semaglutide 2.4 MG (STEP 4)

Most providers recommend switching concentrations rather than splitting injections, because split injections mean two needle sticks per week and twice the opportunity for injection site reactions

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Severe complications from semaglutide remain uncommon, with fewer than 4 emergency department visits per 1,000 patients reported in a Harvard-CDC study
