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The GLP-1 mechanism works differently in this population, and the glucagon-suppressing effect of the drug can cause dangerous hypoglycemia
An ensemble of ZINC database 32 and in-house molecules was used
Discussion In this phase 2, randomized, double-blind, placebo-controlled trial of orforglipron, participants in all dose cohorts (12, 24, 36, and 45 mg) had a greater decrease from baseline in body weight than those in the placebo group, both at 26 weeks (primary end point) and at 36 weeks (secondary end point)
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