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Saxenda is contraindicated (must not be used) in people with: A personal or family history of medullary thyroid carcinoma (MTC) Multiple Endocrine Neoplasia syndrome type 2 (MEN 2), a genetic condition that increases the risk of certain hormone-related tumors Tell your doctor immediately if you notice a lump or swelling in your neck, hoarseness, trouble swallowing, or shortness of breath

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Who Should Be Careful Although the ColonBroom formulation is mostly safe, there are some situations where caution is needed: Pregnancy and Breastfeeding Berberine is generally not recommended during pregnancy or while breastfeeding

In August 2025, the FDA approved semaglutide to treat MASH with moderate to advanced liver fibrosis