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For patients at high risk of cardiovascular events particularly those with established atherosclerotic disease current guidelines from the ADA and ESC now favour GLP-1 receptor agonists as a preferred second-line therapy after metformin
Although rare, serious side effects have been noted, with gallbladder disease and pancreatitis among the most concerning
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Rotate injection sites to prevent tissue damage and ensure consistent absorption
Through activation of these receptors, it enables investigation of integrated endocrine signaling pathways that regulate cellular energy sensing, metabolic enzyme activity, and nutrient responsive signaling in laboratory models[5]
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