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The robust and durable efficacy of dual agonists, such as tirzepatide and CagriSema, and more recently, of the triple agonist retatrutide, has been validated clinically across diverse populations
Dosing, continuation, or discontinuation decisions remain under clinician control throughout participation
Wu, G., et al
Likewise, drug developers therefore engineer analogs with altered amino acids, lipid attachments, or other modifications intended to improve solubility, stability, exposure, and dosing frequency
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