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PMC Article PMC4425239

20 a notoriously hard complication to treat

This preclinical study demonstrates that vitamin B12 supports mitochondrial metabolism through altering gene expression and multiple metabolic pathways

Pretty much all the research on the topic, though, says there are a lot of unanswered questions here, and more research is needed.[ref][ref] Related article : POTS syndrome genes Restless Leg Syndrome: A recent study found people with mast cell activation syndrome were about 3 to 4 times more likely than normal to have restless leg syndrome also.[ref] Related article : Restless Leg Syndrome Genes Lets switch gears and look at how your genes may influence your risk of MCAS