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Microneedle introduction, liposome encapsulation or chemical penetration enhancers (such as azone) can increase its transdermal absorption rate to 15%-25%, bringing the local concentration to the effective threshold (5-10 mM)
The drug works through a novel central pathway, and that novelty means we need to be especially careful in populations where the clinical trial data are thin" [1]
Anti-inflammatory activity: Demonstrates reduction in inflammatory markers in laboratory models
Importantly, the temporal pattern of these side effects is clinically relevant
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