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Semaglutide (used in GLP-1 medications like Ozempic and Wegovy) is a peptide drug, and tesamorelin is an FDA-approved synthetic growth hormone-releasing factor analogue
Currently, 30% of Americans interested in weight loss say they do not use a GLP-1 medication because of cost or insurance coverage, as insurers cut back on GLP-1 coverage
In addition, a multicenter, randomized controlled trial in patients with T2DM without cardiovascular disease also found that the mean carotid intimal thickness and left carotid intimal thickness after sitagliptin treatment were significantly reduced from baseline, with no significant difference on the right side
However, the study also went on to confirm the growing concern that many regained a significant amount of the weight they lost once they stopped taking the GLP-1 medications
