J Exp Bot 53(372):12271236 Wonisch W, Kohlwein SD, Schaur J, Tatzber F, Guttenberger H, Zarkovic N, Winkler R, Esterbauer H (1998) Treatment of the budding yeast Saccharomyces cerevisiae with the lipid peroxidation product 4-HNE provokes a temporary cell cycle arrest in G1 phase
The NAD + -consuming enzymes produce NAM as a byproduct, of which high concentrations inhibit the activity of NAD + -consuming enzymes, providing feedback regulation
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