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Mechanism of Action SGLT2 inhibitors have been shown to reduce all-cause mortality, cardiovascular mortality, and risk for heart failure hospitalizations in patients with HF

The age range in UC patients was 18-64 yr while in controls 20-64 yr

Archives of ophthalmology

From an aesthetic perspective, this matters because: GLP-1 RAs influence body composition, reducing lean mass, which might alter diffusion or uptake of injectables They impact systemic metabolism which may alter the pharmacokinetics or pharmacodynamics of other drugs As more patients on GLP-1 therapy request cosmetic injectables, including botulinum toxin, the potential for interaction becomes clinically relevant