Upon binding to IL12R, the JAK2 was linked to IL12R2, and then STAT4 was phosphorylated, after which the dimerized STAT4 could be transferred to the nucleus to alter gene expression (48, 49)
STUDY LIMITATIONS Lack of Detailed Clinical Data The study relied on ICD coding, which limits access to detailed information about disease activity, previous surgeries, smoking habits, lifestyle factors, and specific ophthalmological findings
Safety Considerations and Provider Evaluation for Non-Overweight Patients Non-overweight patients starting GLP-1 therapy require the same safety monitoring as any candidate: baseline kidney function, liver panels, and screening for personal or family history of thyroid cancer or medullary thyroid carcinoma
Schwartzbaum JA, Cornwell DG