Several small molecules that target mutant p53 have been identified through various strategies, including PRIMA-1 and APR-246 (PRIMA-1 Met ) 6,7 , 3-Benzoylacrylic acid 8 , PK7088 9 , NSC319726 (ZMC1) 10 , stictic acid 11 and 2-sulfonylpyrimidines such as PK-11007 12
We believe there should be a concerted field-wide effort to design studies that can answer gating questions for real-world GLP-1 deployment for addiction: what do clinicians need to know and see to increase confidence in using GLP-1s for patients with SUD or SUD risk
Prescription GLP-1 medications undergo rigorous clinical trials, require medical supervision, and achieve average weight loss of 15-25% in clinical trials
So for example, you know, I have a software on my computer called Dragon Dictation, and that allows me to actually speak, with pretty good accuracy, articles or email