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After one month, the dose should be increased to 7mg unless there are exceptional circumstances requiring delayed escalation

- Rserv aux adultes et adolescents

Repeated the above amino acids coupling and Fmoc deprotection steps with remaining amino acids as per the amino acid sequence of Semaglutide by using Fmoc-Gly- OH, Fmoc-Arg(pbf)-OH, Fmoc-Val-OH, Fmoc-Leu-OH, Fmoc-Trp(Boc)-OH, Fmoc-Ala- OH, Fmoc-Ile-OH, Fmoc-Phe-OH, Fmoc-Glu(OtBu)-OH, Fmoc-Lys(Boc)-OH, Fmoc-Ala- OH, Fmoc-Ala-OH, Fmoc-Gln(Trt)-OH, Fmoc-Gly-OH, Fmoc-Glu(OtBu)-OH, Fmoc-Leu- OH, Fmoc-Tyr(tBu)-OH, Fmoc-Ser(tBu)-OH, Fmoc-Ser(tBu)-OH, Fmoc-Val-OH, Fmoc- Asp(OtBu)-OH, Fmoc-Ser(tBu)-OH, Fmoc-Thr(tBu)-OH, Fmoc-Phe-OH, Fmoc-Thr(tBu)- OH, Fmoc-Gly-OH, Fmoc-Glu(OtBu)-OH coupled to H-Arg(Pbf)-Gly-CTC resin by linear approach to get the title compound

Rev Gastroenterol Disord