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The landmark FLOW trial , published in the New England Journal of Medicine in 2024, demonstrated that semaglutide reduced the risk of major kidney disease events by 24% in patients with type 2 diabetes and chronic kidney disease (hazard ratio 0.76
The next generation of obesity therapies are already involving combinations, either as two separate molecules or by combining two or more targeting moieties in one molecule
di Francesco V, Zamboni M, Dioli A, et al
Although there are some cardioprotective benefits to LC supplementation in certain situations (such as lowering all-cause mortality after MI), the formation of TMAO that goes along with it raises questions regarding long-term cardiovascular safety, particularly for people who already have heart issues [83]
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