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Magnesium hydroxide is another osmotic option, but people with kidney disease or certain heart conditions should not use magnesium products without medical guidance

PubMed , Wilding, John P

Type 2 Diabetes: TRANSCEND-T2D-1 In March 2026, Eli Lilly published topline results from TRANSCEND-T2D-1 the Phase 3 trial of retatrutide in adults with type 2 diabetes

In our future work, we will examine the comparative effectiveness of alternative treatment options for obesity in patients who discontinue semaglutide or tirzepatide, to help patients and their clinicians make informed decisions. In the obese group, the average body weight lost before discontinuation was 8.4%, with a regain rate of 0.5% one year later