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The results are inconsistent

More significant changes in elasticity and hyperpigmentation generally require three to six months of consistent use

Confirmatory secondary endpoints included exercise function assessed by change in 6MWD, overall clinical benefit assessed using a hierarchical composite endpoint (all-cause death, HF events, several thresholds of change in KCCQ-CSS from baseline to 52 weeks and change in 6MWD 30 m) and change in CRP from baseline to 52 weeks