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FIGURE 4 5.2.2 Protecting the blood-brain barrier The BBB is a complex structure consisting of cerebral microvascular endothelial cells, endothelial cell occluding, and claudin, intercellular zonula occludens-1 (ZO-1), astrocyte terminal foot, pericyte, and basement membrane (Mark and Davis, 2002
daily or weekly) to correct deficiency, followed by maintenance (commonly 1 mg IM monthly or as prescribed)
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