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Several factors can influence how well a patient responds to treatment

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A vague sense that something is wrong

Men over 40 typically see: Faster initial scale movement (58 lbs in weeks 14 versus 25 lbs for women) More linear weekly loss patterns Less hormonal water retention masking results Stronger early appetite suppression response Women over 40 typically see: Slower initial scale loss but more dramatic body composition change relative to scale weight Greater week-to-week scale fluctuation due to cycle and hormonal factors Faster muscle and waist response when protein intake is adequate More pronounced GI side effects at the same per-kilogram dose The most important difference is in the metrics that matter