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Gastrointestinal side effects can lead to fluid losses

Meanwhile, liraglutide's share decreased from 42% to 12% among users with diabetes and from 58% to 21% among those without diabetes, although its estimated absolute number of users without diabetes increased

This action triggers a cascade of events

It is common practice to initiate insulin therapy for patients who presentwith the following: a blood glucose level of 16.7 mmol/L (300 mg/dL) or greater or an HbA1c concentration higher than 10% (86 mmol/mol), symptoms of hyperglycemia (namely polyuria or polydipsia), or evidence of catabolic weight loss or ketosis (Figure 2)