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Age-related considerations include: Younger adults (18-30) May tolerate dose escalation well but should still follow standard protocols

These include: N-methyl-D-aspartate (NMDA) receptors and gamma-aminobutyric acid (GABA) receptors : NMDA receptors are linked to glutamate, a vital neurotransmitter that facilitates brain excitation, while GABA receptors are associated with inhibitory neurotransmission, playing a significant role in calming the brain

The present review emphasizes the need to find the heteromeric partners of the D 4 R and to establish the differential functional and pharmacological role of its polymorphic variants