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Among the tested formulations, PNP-1-10-0.05 Sema-1.8 mg/mL exhibited the most favorable safety profile across all evaluated tissues, while PNP-1-10-0.05 TZP-4.5 mg/mL, though eliciting a modest increase in localized tissue response, remained substantially more biocompatible than daily bolus TZP
The side effects of tirzepatide are the same as the GLP-1 medications, primarily nausea and gastrointestinal disturbance
This literature review was conducted following the PICO Framework, with details available in Supplementary material 1
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