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Even mild endothelial dysfunction (e.g., due to oxidative stress or inflammation) impairs this regulatory axis, facilitating arterial stiffening and predisposing individuals to hypertension
Subsequent studies have confirmed reductions in visceral adipose tissue (VAT), the metabolically active fat surrounding internal organs that contributes to cardiometabolic risk
This weight reduction was not merely cosmetic
DOI 10.1093/emboj/20.13.3459
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