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theoretical risks include increased hypoglycaemia, unpredictable cardiovascular effects, and compounded uncertainty from two incompletely characterised compounds

At the cellular level, insulin resistance can be defined as reduced signal transduction along the PI3KAKTmTOR pathway per unit of insulin, resulting in decreased glucose uptake per unit of insulin in adipocytes and skeletal muscle or decreased suppression of hepatic gluconeogenesis

Without the CKD code, the manifestation has no reference point and the claim fails

This is fundamentally different from how minoxidil works, which primarily dilates blood vessels, or how finasteride works, which blocks DHT production