PMID: 21875351): The study showed randomized double blind placebo controlled RCT in 40 healthy adults showing no significant changes in oxidative stress biomarkers or RBC glutathione after 4 weeks of 500 mg twice daily oral GSH Oral supplementation with liposomal glutathione elevates body stores of glutathione and markers of immune function , published in European Journal of Clinical Nutrition (Sinha R et al., 2018
Several independent studies have also shown that treatment with arimoclomol, a co-inducer of heat shock proteins, is protective against toxic mutant SOD1 aggregates, delays disease progression and improves motor function in SOD1 G93A mice (Kieran et al., 2004
However, Dr Gary Deed, Chair of RACGP Specific Interests Diabetes, told newsGP the recent spike in public concern is not necessarily mentioning high-quality evidence
Notably, the Canagliflozin and Renal Events in Diabetes with Established Nephropathy Clinical Evaluation (CREDENCE) trial, the first dedicated kidney outcome trial evaluating canagliflozin in people with type 2 diabetes mellitus and CKD, demonstrated a substantial reduction in the risk of kidney events [46]