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Description

G.SmithR

Medicinal chemical properties of successful central nervous system drugs

doi: 10.3390/ijms21113847 44 BacherAEberhardtSFischerMKisKRichterG

Mutations in both proB and proA , the first two genes in L-proline biosynthesis, provided a new pathway for -glutamyl cysteine formation via the selective interception of ProB-bound -glutamyl phosphate by amino acid thiols, likely through an S-to-N acyl shift mechanism