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Across roughly 3,400 patients on semaglutide 2.4 mg: Nausea hit 43.9 percent of semaglutide patients vs 16.1 percent on placebo Diarrhea hit 29.7 percent Vomiting hit 24.5 percent Constipation hit 24.2 percent Discontinuation for GI ran 4.3 percent 99.5 percent of all adverse events were non-serious The 2025 FAERS pharmacovigilance signals worth flagging in user reviews include acute pancreatitis, acute kidney injury, gallbladder injury, and NAION (a form of optic neuropathy)

For fatigue: Prioritize sleep and gentle movement like walking