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While adaptive circadian remodeling may preserve functional stability under changing biological conditions, pathological circadian misalignment is typically associated with disease states, accelerated aging, neurodegeneration, metabolic disorders, or chronic exposure to chronodisruptive factors such as irregular light exposure or feeding patterns ( Melatonin is not only the principal hormonal output of the circadian system but also a pleiotropic molecule with chronobiotic, antioxidant, immunomodulatory, and neuroprotective properties

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Wijsenbeek M, Suzuki A, Maher TM

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