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However, native GLP-1 is rapidly degraded by dipeptidyl peptidase-4 (DPP-4) and cleared renally, resulting in a plasma half-life of approximately 23 min [20, 21]
Experts now specify the following fiber targets for those on a GLP-1: 25 g/day of fiber for women, 30 g/day for men and 35 g/day for those with diabetes (Sievenpiper et al 2026) Healthy fats found in olive oil, nuts, seeds, avocado, fatty fish Hydration: 23 L/day for digestion, bowel health, kidneys and energy, up to 4 L/day depending in climate and activity
Furthermore, the applications of microdosing extend beyond mere weight management, showing promise in areas of metabolic optimisation and overall wellness enhancement
Importantly, GLP-1 and glucagon act through structurally related receptors and both peptides exhibit similar amino acid N-terminal sequences, a domain essential for proper interaction with their receptors
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