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The essential link between the mitochondrial carnitine transport and FAO is demonstrated by the life-threatening inherited carnitine/acylcarnitine translocase deficiency (OMIM 613698) that, in contrast to the PCD caused by OCTN2 defects, cannot be compensated by the administration of carnitine (Indiveri et al., 2011)
On June 10th, researchers from Eli Lilly published findings of a randomized phase 2a clinical trial in "Nature Medicine" titled Triple hormone receptor agonist retatrutide for metabolic dysfunction-associated steatotic liver disease: a randomized phase 2a trial. The study indicated that Retatrutide (LY3437943), a GLP-1R-related triple receptor agonist currently under clinical development, demonstrated significant efficacy and favorable safety in the treatment of metabolic dysfunction-associated steatotic liver disease (MASLD)
Possible side effects include: Nausea Headache Flushing Temporary increases in blood pressure If side effects are persistent, severe, or concerning, contact your provider
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