While these drugs, which mimic the effects of the hormone GLP-1 by slowing stomach emptying and promoting a feeling of fullness, are often viewed as a quick solution, rapid weight loss is associated with bone density reduction, as the reduced load the weight, pressure or stress your bones have to bear decreases the need to form new skeletal tissue, as the more pressure on your bones, the more your bones are forced to become stronger
Potential areas of expansion include: Cardiovascular outcomes: A dedicated CVOT, if not already required as a post-marketing commitment, would evaluate whether orforglipron reduces MACE in patients with established cardiovascular disease or high cardiovascular risk, following the precedent set by the SELECT trial for semaglutide
Some of the injection-pen-related patents in Canada run until at least 2033, potentially delaying Wegovy generics despite the core molecule being unprotected
Saxenda does come with a high list price, yet that number is mostly a reference point rather than the amount most people actually pay out of pocket