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Further experiments confirmed that acrylamide decreased mitochondrial membrane potential (MMP) and increased ROS production and Nrf2 levels, leading to GSH deactivation and GPX4 degradation and inevitably inducing oxidative stress and ferroptosis (47,104)

Animal studies routinely use body-weightbased dosing that, once scaled to human physiology, can exceed safety limits set for oral consumption

Medications and Supplements Anticoagulants (warfarin, apixaban, rivaroxaban), antiplatelet drugs (aspirin, clopidogrel), and certain anti-inflammatories (NSAIDs) increase bleeding risk and can lead to easier bruising

Doses should be spaced evenly throughout the day (every three or four hours) preferably during or following meals and should be consumed slowly in order to maximize tolerance