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While rhabdomyolysis has not been established as a recognized complication of GLP-1 medications, any patient presenting with severe muscle pain and dark or cola-colored urine requires emergency medical attention
STEP-1 (NEJM 2021) established the weight-loss efficacy of semaglutide 2.4mg: 1,961 adults with obesity, mean 14.9% weight loss at 68 weeks versus 2.4% on placebo
Preexisting health conditions also play a crucial role in determining semaglutide dosage
To the best of our knowledge, this is the first study ever conducted to investigate the relationship between endogenous GLP-1 levels and glycaemic control as well as insulin responses to DPP-IV inhibition in the form of linagliptin therapy in both prediabetes and T2D subjects
