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Hernndez A et al
doi: 10.1155/2016/1287128 189 DorranceAMNevianiPFerenchakGJHuangXNicoletDMaharryKSet al
While ROS can function as second messengers regulating cellular reproduction, growth, differentiation, and signaling when maintained at optimal concentrations and dynamic equilibrium, exceeding critical ROS thresholds induces oxidative stress, leading to DNA damage, protein denaturation, and lipid peroxidationkey factors in CHD development
In the rats treated with OLZ coinciding with ZnSO 4 at a dose of 50 mg/kg (G3), the examination section showed moderate improvement such as congestion of the central vein, minimal inflammatory cells with slightly dilated blood sinusoids, and a mild increase in Kupffer cells (Fig
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