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Despite current challenges such as response threshold control, drug loading efficiency, and biosafety, future improvements can be achieved through machine learning-assisted optimization of response group structures (e.g., thiol groups, borate esters) to enhance selectivity and precise regulation

For antidepressants like SSRIs, absorption may be delayed, but dose adjustments are rarely needed

Low-income beneficiaries who have reduced cost-sharing can't use their subsidy for weight-loss drug prescriptions, so the copayment could be a financial barrier

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