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In the SURMOUNT-1 trial, patients lost an average of 22.5% of their total body weight, which is significantly higher than semaglutide in head-to-head data
Lancet 373 , 10831096 (2009)
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162,339 In addition, the nuclear export of acetylated FOXOs further inhibits autophagy, highlighting that transcription factor function is profoundly influenced by posttranslational modification mechanisms mediated by epigenetic regulators
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